What to do if you miss a dose of Spinraza depends on whether you’ve missed a loading dose or a maintenance dose. You’ll receive your first maintenance dose 4 months after the last loading dose (fourth injection). Your remaining doses of Spinraza are called maintenance doses. Your first four doses of Spinraza are called loading doses. Your dosing schedule for Spinraza will typically include loading dose injections and maintenance dose injections.
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Does interact with other drugs you are taking? It is given as an intrathecal injection, which is an injection in the area around the spinal cord. Keep all of your appointments to have your urine (pee) checked before starting and before each dose of Spinraza. Keep all appointments to have your blood checked before starting and before each dose of Spinraza. Having a low level of platelets may increase your risk of bleeding. While less common, the most serious side effects of Spinraza are described below, along with what to do if they happen.
After the loading doses, you’ll likely receive the maintenance (ongoing) dosage of Spinraza. The results of these tests will help your doctor determine if it’s safe for you to receive the drug. This protein is important for motor neurons to work. Spinraza is used to treat spinal muscular atrophy (SMA) in adults and children of any age. These reports occurred after the drug became available for use. Instead, Spinraza is a type of drug called an antisense oligonucleotide.
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These side effects may vary depending on when the spinal muscular atrophy (SMA) began. Like most drugs, Spinraza may cause mild or serious side effects. The fourth loading dose is given 30 days after the third dose. Then you’ll wait another 14 days for the third dose. After the first loading dose of Spinraza, you’ll receive the second dose 14 days later.
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The pharmacokinetics of nusinersen in patients with renal or hepatic impairment has not been studied. The mean terminal elimination half-life in CSF is estimated at 135 to 177 days. Presence of nusinersen was also demonstrated in neurons and other cell types in the spinal cord and brain, and peripheral tissues such as skeletal muscle, liver, and kidney.
A study evaluating the long-term effects of Spinraza is planned but hasn’t started yet. These doses help keep steady levels of the drug in your body over time. Then you’ll receive the fourth dose 30 days after the third dose. For the first three doses of Spinraza, you’ll receive an injection every 14 days. These doses help quickly raise the level of the drug in your body.
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But it has been reported by people who’ve used the drug after it became available to the public. This side effect wasn’t common in clinical studies of the drug. In rare cases, Spinraza may cause hydrocephalus (a buildup of spinal fluid in the brain). For more information, see “Mild side effects” and “Serious side effects” above. But it’s expected that side effects from Spinraza are generally the same in both children and adults.
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